Making the medicine go down: can you change the medicine?
I realize that if you are talking about a perscription, then that's that, and there may be no other options.
However, if you are talking about OTC medications, you may be able to try different brands or formulations. While my baby is teething, we offer pain reliever. My daughter hates all pain relievers EXCEPT dye-free CVS generic ibuprofen--that she takes without issue. We've tried name brands, and even CVS generic with dye, and she refuses them. I'm glad we found a version that works, and maybe if you fall into this situation, you can too.